西南民族大学学报(自然科学版)

优化葛通颗粒的制备工艺.采用L₉(3⁴)正交试验设计，将加水量、煎煮时间和煎煮次数作为主要考察因素，结合葛根素转移率及浸膏得率两项指标，对葛通颗粒的提取参数进行优化筛选，并考察浸膏相对密度、辅料种类及药辅比对葛通颗粒成型性影响.结果显示，葛通颗粒提取最优工艺为原方药材加10倍量水，煎煮3次，每次1 h；最佳成型工艺为浓缩药液至相对密度1.20～1.25(20℃)，按浸膏与糊精1∶1.8～1∶2.0比例混合制粒.优选的制备工艺操作简便，且稳定性与重复性较好，可为葛通颗粒的工业化生产提供参考依据.

To optimize the preparation process of Getong Granules, an L₉(3⁴) orthogonal experimental design was employed, with water volume, decoction time, and decoction frequency selected as the main factors. Using the transfer rate of puerarin and the extraction yield as the evaluation indices, the extraction parameters of Getong Granules were optimized and screened. The effects of the relative density of the extract, the type of excipient, and the drug-to-excipient ratio on the formability of Getong Granules were also investigated. The optimal extraction process was as follows: the original herbal materials were decocted three times with 10 times the amount of water, 1 hour once. The optimal forming process involved concentrating the decoction to a relative density of 1.20-1.25(20 °C) and granulating with dextrin at an extract-to-dextrin ratio of 1∶1.8–1∶2.0. The optimized preparation process is simple to operate and exhibits good stability and repeatability, providing a reference for the industrial production of Getong Granules.